English version   

                                       课题组教员                   

                            

                                                 

    张雷,教授 

    天津大学化工学院生物工程系

     办公室地址:天津大学北洋园校区54号教学楼E329

 

  

                            

      

    齐海山,讲师

     天津大学化工学院生物工程系

     办公室地址:天津大学北洋园校区54号教学楼E329

         

                                     

      

        杨静,讲师

          天津大学化工学院生物工程系

          办公室地址:天津大学北洋园校区54号教学楼E330

         

                                     

                                   课题组学生                            

                            

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                                           刘   敏                   解长海                   张   晨                        可   佳             

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                                           蔡诚诚                   张相宇                   米佳黎                 

                               

                                           陈佚升                   符岱涵                    何冰清                        林   磊

                                           刘虹汝               

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                                                                     姓   名                                           学   位                                           届   数                         


                                                                      蔡娜娜                                            硕   士                                           2017                         


                                                                      翟洪稳                                            硕   士                                           2017                         


                                                                      杨   静                                            博   士                                           2018                         


                                                                      许   瞳                                            博   士                                           2018                         


                                                                      潘   超                                            硕   士                                           2018                         


                                                                      胡冠南                                            硕   士                                           2018                         


                                                                      张嘉敏                                            博   士                                           2019                         


                                                                      杜   岩                                            硕   士                                           2019                         


                                                                      郑伟伟                                            硕   士                                           2019                         


                                                                      宋佳音                                            硕   士                                           2019                         


                                           潘   超                   胡冠南

                                                                                                                                  

                                                          

蔡娜娜(左),翟洪稳(右)和张雷教授(中)

                           

                                                          

杨静,潘超和胡冠南毕业合影

                           

                                                          

许瞳(右)和张雷教授(左)

                           

                                                          

郑伟伟(左一),宋佳音(左二),张嘉敏(左三),杜岩(右一)和张雷教授(右二)

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                              课题组合影       

                                                  2019.06                                                                           2019.01

                                                                                                         

                                                  2018.06                                                                           2017.05

                                                                                                         

                                                  2016.09                                                                           2016.05

                                                                                                         

                                                  2015.06                                                                           

                                                        

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                              Publications             


2019

1. Min Liu#, Xiangyu Zhang#, Hongshuang Guo, Yingnan Zhu, Chiyu Wen, Xiaojie Sui, Jing Yang*, Lei Zhang*. Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers. Biomacromolecules, 2019, DOI: 10.1021/acs.biomac.9b01024.

2. Jiamin Zhang, Jia Ke, Yingnan Zhu, Jiayin Song, Jing Yang, Chiyu Wen, Lei Zhang*. Influence of divalent cations on the biofouling behaviors of alginate hydrogels. Biomedical Materials, 2019, DOI: 10.1088/1748-605X/ab4542.

3. Chiyu Wen#, Hongshuang Guo#, Haoyu Bai, Tong Xu, Min Liu, Jing Yang, Yingnan Zhu, Weiqiang Zhao, Jiamin Zhang, Moyuan Cao*, Lei Zhang*. Beetle-inspired hierarchical anti-bacterial interface for reliable fog harvesting. ACS Applied Materials & Interfaces, 2019, DOI: 10.1021/acsami.9b11862.

4. Qingsi Li#, Jing Yang#, Nana Cai, Jiamin Zhang, Tong Xu, Weiqiang Zhao, Hongshuang Guo, Yingnan Zhu, Lei Zhang*. Hemocompatible hemoadsorbent for effective removal of proteinbound toxin in serum. Journal of Colloid and Interface Science, 2019, 555: 145-156.

5. Wanjun Chen#, Yingnan Zhu#, Zhe Zhang, Yue Gao, Wenxin Liu, Qinggele Borjihan, Huihui Qu, Yana Zhang, Yanling Zhang, Yan-Jie Wang*, Lei Zhang*, Alideertu Dong*. Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy. Chemical Engineering Journal, 2019, DOI: 10.1016/j.cej.2019.122238.

6. Weiqiang Zhao#, Jing Yang#, Hongshuang Guo, Tong Xu, Qingsi Li, Chiyu Wen, Xiaojie Sui, Cunguo Lin, Jinwei Zhang*, Lei Zhang*. Slime-resistant marine anti-biofouling coating with PVP-based copolymer in PDMS matrix. Chemical Engineering Science, 2019, 207: 790-798.

7. Haishan Qi#, Chen Zhang#, Hongshuang Guo, Weiwei Zheng, Jing Yang, Xiao Zhou, Lei Zhang*. Bioinspired Multifunctional Protein Coating for Antifogging, Self-Cleaning, and Antimicrobial Properties. ACS Applied Materials & Interfaces, 2019, 11(27): 24504-24511.

8. Hongshuang Guo#, Jing Yang#, Weiqiang Zhao, Tong Xu, Cunguo Lin, Jinwei Zhang*, Lei Zhang*. Direct formation of amphiphilic crosslinked networks based on PVP as a marine anti-biofouling coating. Chemical Engineering Journal, 2019, 374: 1353-1363.

9. Jing Yang#, Xiaojie Sui#, Qingsi Li, Weiqiang Zhao, Jiamin Zhang, Yingnan Zhu, Pengguang Chen, Lei Zhang*. In Situ Encapsulation of Postcryopreserved Cells Using Alginate Polymers and Zwitterionic Betaine. ACS Biomaterials Science & Engineering, 2019, 5(5): 2621-2630.

10. Jing Yang#, Chiyu Wen#, Chao Pan, Hongshuang Guo, Weiqiang Zhao, Jiamin Zhang, Yingnan Zhu, Yumiao Zhang*, Lei Zhang*. Nanoliposomal Multi-Drug Delivery System with Reduced Toxicity and Multi-Drug Resistance. Journal of Materials Science, 2019, 54(13): 9718-9728.

11. Hongshuang Guo#, Jing Yang#, Tong Xu, Weiqiang Zhao, Jiamin Zhang, Yingnan Zhu, Chiyu Wen, Qingsi Li, Xiaojie Sui, Lei Zhang*. A robust cotton textile based material for high flux oil-water separation. ACS Applied Materials & Interfaces, 2019, 11(14): 13704-13713.

12. Haishan Qi#, Weiwei Zheng#, Chen Zhang, Xiao Zhou, Lei Zhang*. Novel Mussel-Inspired Universal Surface Functionalization Strategy: Protein-Based Coating with Residue-Specific Post-Translational Modification in Vivo. ACS Applied Materials & Interfaces, 2019, 11(13): 12846-12853.

13. Jiamin Zhang#, Yingnan Zhu#, Jiayin Song, Tong Xu, Jing Yang, Yan Du, Lei Zhang*. Rapid and Long-Term Glycemic Regulation with a Balanced Charged Immune-Evasive Hydrogel in T1DM Mice. Advanced Functional Materials, 2019, 29: 1900140.

14. Xiaojie Sui, Chiyu Wen, Jing Yang, Hongshuang Guo, Weiqiang Zhao, Qingsi Li, Jiamin Zhang, Yingnan Zhu, Lei Zhang*. Betaine combined with membrane stabilizers enables solvent-free whole blood cryopreservation and one-step cryoprotectant removal. ACS Biomaterials Science & Engineering, 2019, 5(2): 1083-1091.

15. Jiayin Song#, Yingnan Zhu#, Jiamin Zhang, Jing Yang, Yan Du, Weiwei Zheng, Chiyu Wen, Yumiao Zhang, Lei Zhang*. Encapsulation of AgNPs within zwitterionic hydrogels for highly efficient and antifouling catalysis in biological environments. Langmuir, 2019, 35(5): 1563-1570.

16. Jing Yang, Xiaojie Sui, Chiyu Wen, Chao Pan, Yingnan Zhu, Jiamin Zhang, Lei Zhang*. A hemocompatible cryoprotectant inspired by freezing-tolerant plants. Colliods and Surfaces B: Biointerfaces, 2019, 176: 106-114.

2018

17. Yingnan Zhu, Jiayin Song, Jiamin Zhang, Jing Yang, Weiqiang Zhao, Hongshuang Guo, Tong Xu, Xiao Zhou, Lei Zhang*. Encapsulation of laccase within zwitterionic poly-carboxybetaine hydrogels for improved activity and stability. Catalysis Science & Technology, 2018, 8(20): 5217-5224.

18. Haishan Qi, Weiwei Zheng, Xiao Zhou, Chen Zhang, Lei Zhang*. Mussel-inspired chimeric protein as a novel facile antifouling coating. Chemical Communications, 2018, 54(80): 11328-11331.

19. Lei Zhang, Guannan Hu, Yan Du, Lei Gao, Haishan Qi*. A facile modification to improve the biocompatibility and adsorbability of activated carbon with zwitterionic hydrogel. Journal of Materials Science: Materials in Medicine, 2018, 29(8): 113.

20. Lei Zhang, Yan Du, Jiayin Song, Haishan Qi*. Biocompatible magnetic nanoparticles grafted by poly (carboxybetaine acrylamide) for enzyme immobilization. International Journal of Biological Macromolecules, 2018, 118(Pt A): 1004-1012.

21. Tong Xu, Jiamin Zhang, Yingnan Zhu, Weiqing Zhao, Chao Pan, Hongyan Ma, Lei Zhang*. A poly(hydroxyethyl methacrylate)-Ag nanoparticle porous hydrogel for simultaneous in vivo prevention of the foreign-body reaction and bacterial infection. Nanotechnology, 2018, 29(39): 395101.

22. Hongshuang Guo, Tong Xu, Jiamin Zhang, Weiqiang Zhao, Jinwei Zhang, Cunguo Lin, Lei Zhang*. A multifunctional anti-fog, antibacterial, and self-cleaning surface coating based on poly (NVP-co-MA). Chemical Engineering Journal, 2018, 351: 409-417.

23. Weiqiang Zhao, Yingnan Zhu, Jiamin Zhang, Tong Xu, Qingsi Li, Hongshuang Guo, Jinwei Zhang, Cunguo Lin*, Lei Zhang*. A comprehensive study and comparison of four types of zwitterionic hydrogels. Journal of Materials Science, 2018,53(19): 13813-13825.

24. Jiamin Zhang, Yingnan Zhu, Jiayin Song, Jing Yang, Chao Pan, Tong Xu, Lei Zhang*. Novel Balanced Charged Alginate/PEI Polyelectrolyte Hydrogel that Resists Foreign-Body Reaction. ACS applied materials & interfaces, 2018, 10(8): 6879-6886.

25. Ruying Chen, Hongyan Ma, Lei Zhang, James D Bryers*. Precision-Porous Templated Scaffolds of Varying Pore Size Drive Dendritic Cell Activation. Biotechnology & Bioengineering, 2018, 115(4): 1086-1095.

26. Jie Zhang, Wei Guo, Changgen Shi, Yan Zhang, Chunyan Zhang, Lei Zhang, Rongfang Wang*, Baishen Pan*. Copy Number Variations in Serum Amyloid A Play a Role in the Determination of its Individual Baseline Concentrations. Clinical Chemistry, 2018, 64(2): 402-404.

27. Haishan Qi, Yan Du, Guannan Hu, Lei Zhang*. Poly(carboxybetaine methacrylate)-functionalized magnetic composite particles: A biofriendly support for lipase immobilization. International Journal of Biological Macromolecules, 2018, 107: 2660-2666.

28. Tong Xu, Jing Yang, Jiamin Zhang, Yingnan Zhu, Qingsi Li, Chao Pan, Lei Zhang*. Facile modification of electrospun fibrous structures with antifouling zwitterionic hydrogels. Biomedical Materials, 2018, 13(1): 015021.

2017

29. Jing Yang#, Chao Pan#, Jiamin Zhang, Xiaojie Sui, Yingnan Zhu, Chiyu Wen, Lei Zhang*. Exploring the Potential of Biocompatible Osmoprotectants as Highly Efficient Cryoprotectants. ACS Applied Materials & Interfaces, 2017, 9(49), 42516-42524.

30. Yingnan Zhu, Jiamin Zhang, Jiayin Song, Jing Yang, Tong Xu, Chao Pan, Lei Zhang*. One-Step Synthesis of an Antibacterial and Pro-Healing Wound Dressing That can Treat Wound Infections. Journal of Materials Chemistry B, 2017, 5, 8451-8458.

31. Haishan Qi, Yan Du, Xiao Zhou, Weiwei Zheng, Lei Zhang*, Jianping Wen, Liming Liu. Engineering a new metabolic pathway for itaconate production in Pichia stipitis from xylose. Biochemical Engineering Journal, 2017, 126: 101-108.

32. Hongwen Zhai#, Jing Yang#, Jiamin Zhang, Chao Pan, Nana Cai, Yingnan Zhu, Lei Zhang*. Natural zwitterionic l-Carnitine as efficient cryoprotectant for solvent-free cell cryopreservation. Biochemical and Biophysical Research Communications, 2017, 489(1): 76-82.

33. Nana Cai, Qingsi Li, Jiamin Zhang, Tong Xu, Weiqiang Zhao, Jing Yang, and Lei Zhang*. Antifouling Zwitterionic Hydrogel Coating Improves Hemocompatibility of Activated Carbon Hemoadsorbent. Journal of Colloid and Interface Science, 2017, 503: 168-177.

34. Jing Yang, Chao Pan, Xiaojie Sui, Nana Cai, Jiamin Zhang, Yingnan Zhu, and Lei Zhang*. The Hypothermic Preservation Of Mammalian Cells with Assembling Extracellular-Matrix-Mimetic Microparticles. Journal of Materials Chemistry B, 2017, 5(8): 1535-1541.

2016

35. Jing Yang, Nana Cai, Hongwen Zhai, Jiamin Zhang, Yingnan Zhu and Lei Zhang*. Natural Zwitterionic Betaine Enables Cells to Survive Ultrarapid Cryopreservation. Scientific Reports, 2016, 6: 37458.

36. Hongchen Liu, Baolong Xie, Xiaoyan Dong, Yongjian Wang, Lei Zhang, Fufeng Liu, Yan Sun*. Negetively charged hydrophobic nanoparticles inhibit amyloid beta-protein fibrillation: The presence of an optimal charged density. Reactive and Functional Polymers, 2016, 103: 108-116.

37. Zhiqiang Jiang, Xiaoyan Dong, Hu Liu, Yongjian Wang, Lei Zhang, Yan Sun*. Mutifunctionality of self-assembled nanogels of curcumin-hyaluronicacid conjugates on inhibiting amyloid beta-protein fibrillation and cytotoxicity. Reactive and Functional Polymers, 2016,104: 22-29.

38. Jing Yang, Yingnan Zhu, Tong Xu, Chao Pan, Nana Cai, He Huang and Lei Zhang*. The Preservation of Living Cells with Biocompatible Microparticles. Nanotechnology, 2016, 27(26): 265101.

39. Yingnan Zhu, Jiamin Zhang, Jing Yang, Chao Pan, Tong Xu, Lei Zhang*. Zwitterionic Hydrogels Promote Skin Wound Healing. Journal of Materials Chemistry B, 2016, 4, 5105-5111.

Before 2015

40. Tao Bai, Fang Sun, Lei Zhang, Andrew Sinclair, Sijun Liu, Jean-Rene Ella-Menye, Ying Zheng, and Shaoyi Jiang*. Restraint of the Differentiation of Mesenchymal Stem Cells by a Nonfouling Zwitterionic Hydrogel. Angewandte Chemie International Edition, 2014, 53(47): 12729-12734.

41. Lin Yan, Lei Zhang, Hongyan Ma, David Chiu, and James D. Bryers*. A Single B-Repeat of Staphylococcus epidermidis Accumulation-Associated Protein Induces Protective Immune Responses in an Experimental Biomaterial-Associated Infection Mouse Model. Clinical and Vaccine Immunology, 2014, 21(9), 1206-1214.

42. Wei Yang, Sijun Liu, Tao Bai, Andrew J. Keefe, Lei Zhang, Jean-Rene Ella-Menye, Yuting Li, and Shaoyi Jiang*. Poly(carboxybetaine) Nanomaterials Enable Long Circulation and Prevent Polymer-Specific Antibody Production. Nano Today, 2014, 9(1):10-16.

43. Fang Sun, Tao Bai, Lei Zhang, Jean-Rene Ella-Menye, Sijun Liu, Ann K. Nowinski, and Shaoyi Jiang, and Qiuming Yu*. Sensitive and Fast Detection of Fructose in Complex Media via Symmetry Breaking and Signal Amplification Using Surface-Enhanced Raman Spectroscopy. Analytical Chemistry, 2014, 86(5): 2387–2394.

44. Tao Bai, Sijun Liu, Fang Sun, Andrew Sinclair, Lei Zhang, Qing Shao, and Shaoyi Jiang*. Zwitterionic Fusion in Hydrogels and Spontaneous and Time-Independent Self-Healing under Physiological Conditions. Biomaterials, 2014, 35(13): 3926–3933.

45. Lei Zhang, Zhiqiang Cao, Tao Bai, Louisa Carr, Jean-Rene Ella-Menye, Colleen Irvin, Buddy D. Ratner, and Shaoyi Jiang*. Zwitterionic Hydrogels Implanted in Mice Resist The Foreign-Body Reaction. Nature Biotechnology, 2013, 31(6): 553-556.

46. Lei Zhang, Andrew Sinclair, Zhiqiang Cao, Jean-Rene Ella-Menye, Xuewei Xu, Louisa Carr, Suzie H. Pun, and Shaoyi Jiang*. Hydrolytic Cationic Ester Microparticles for High Efficiency DNA Vaccine Delivery. Small, 2013, 9(20): 3439–3444.

47. Hongyan Ma, Erica T. Darmawan, Min Zhang, Lei Zhang, and James D. Bryers*. Development of A Poly (Ether Urethane) System for the Controlled Release of Two Novel Anti-Biofilm Agents Based on Gallium or Zinc and Its Efficacy to Prevent Bacterial Biofilm Formation. Journal of Controlled Release, 2013, 172(3): 1035-1044.

48. Yongheng Zhu*, Daqian Wang, Lei Zhang, Fang Sun, Jiaqiang Xu, Shaoyi Jiang, and Qiuming Yu. In Situ Controlled Growth of Well-Dispersed Au Nanoparticles Inside The Channels of SBA-15 Using A Simple, Bio-Inspired Method for Surface-Enhanced Raman Spectroscopy. RSC advances, 2013, 3(26): 10154-10157.

49. Andrew Sinclair, Tao Bai, Louisa Carr, Jean Rene Ella-Menye, Lei Zhang, Shaoyi Jiang. Engineering and Characterizing Hydrolytic Ester Polymers for Improved Gene Transfer without Cytotoxicity. Biomacromolecules, 2013, 14(5): 1587-1593.

50. Lei Zhang, Zhiqiang Cao, Yuting Li, Jean-Rene Ella-Menye, Tao Bai, and Shaoyi Jiang*. Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation. ACS Nano, 2012, 6(8): 6681–6686.

51. Zhiqiang Cao#, Lei Zhang#, and Shaoyi Jiang*. Superhydrophilic Zwitterionic Polymers Stabilize Liposomes. Langmuir, 2012, 28(31): 11625–11632.

52. Lei Zhang, Jiajie Xu, Luo Mi, Heng Gong, Shaoyi Jiang and Qiuming Yu*. Multifunctional Magnetic-Plasmonic Nanoparticles for Fast Concentration and Sensitive Detection of Bacteria Using SERS. Biosensors and Bioelectronics, 2012, 31(1): 130-136.

53. Jianxin Wang, Yongzhuo Huang, Allan E. David, Beata Chertok, Lei Zhang, Faquan Yu, and Victor C. Yang*. Magnetic Nanoparticles for MRI of Brain Tumors. Current Pharmaceutical Biotechnology, 2012, 13(12): 2403-2416.

54. Zhiqiang Cao, Luo Mi, Jose Mendiola, Jean-Rene Ella-Menye, Lei Zhang, Hong Xue and Shaoyi Jiang*. Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria. Angewandte Chemie International Edition, 2012, 124(11): 2602-2605.

55. Lei Zhang, Hong Xue, Zhiqiang Cao, Andrew Keefe, Jinnan Wang and Shaoyi Jiang*. Multifunctional and Degradable Zwitterionic Nanogels for Targeted Delivery, Enhanced MR Imaging, Reduction-Sensitive Drug Release, and Renal Clearance. Biomaterials, 2011, 32(20): 4604-4608.

56. Lei Zhang, Hong Xue, Changlu Gao, Louisa Carr, Jinnan Wang, Baocheng Chu, and Shaoyi Jiang*. Imaging and Cell Targeting Characteristics of Magnetic Nanoparticles Modified by A Functionalizable Zwitterionic Polymer with Adhesive 3,4-dihydroxyphenyl-L-alanine Linkages. Biomaterials, 2010, 31(25): 6582–6588.

57. Lei Zhang, Faquan Yu, Faquan Yu, Adam J. Cole, Beata Chertok, Allan E. David, Jingkang Wang, and Victor C. Yang*. Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging. AAPS Journal, 2009, 11(4): 693-699.

58. Jiajie Xu, Lei Zhang, Heng Gong, Jiri Homola, and Qiuming Yu*. Tailoring Plasmonic Nanostructures for Optimal SERS Sensing of Small Molecules and Large Microorganisms. Small, 2011, 7(3): 371-376.

59. Faquan Yu, Lei Zhang, Yongzhuo Huang, Kai Sun, Allan E. David, and Victor C. Yang*. The Magnetophoretic Mobility and Superparamagnetism of Core-Shell Iron Oxide Nanoparticles with Dual Targeting and Imaging Functionality. Biomaterials, 2010, 31(22): 5842-5848.

60. Wei Yang, Lei Zhang, Shanlin. Wang, Andrew D. White, and Shaoyi Jiang*. Functionalizable and Ultra Stable Nanoparticles Coated with Zwitterionic Poly(Carboxybetaine) in Undiluted Blood Serum. Biomaterials, 2009, 30(29): 5617–5621.

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